From DeveloperWorks, The top 15 WebSphere MQ best practices

Many articles and books offer recommendations for designing message queuing and integrating it into applications. This article simplifies this maze by listing 15 or so widely recognized best practices for using
WebSphere MQ to implement message queuing. This article describes the most common best practices in designing, building, running, and maintaining WebSphere MQ solutions in order to achieve the full benefits of WebSphere MQ.

I don’t deal with MQ much on my day-to-day, but I’m a sucker for Top x lists. Here’s one from IBM, I’m sure there are concepts contained within that can be applied to the WebSphere Application Server Default Messaging engine